Tocotrienols Attenuate White Adipose Tissue Accumulation and Improve Serum Cholesterol Concentration in High-Fat Diet-Treated Mice

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Tocotrienols Attenuate White Adipose Tissue Accumulation and Improve Serum Cholesterol Concentration in High-Fat Diet-Treated Mice   Tocotrienols (T3s), which are vitamin E homologs, have not only antioxidant function but also inhibitory effects on body weight gain and hepatic lipid droplet accumulation. However, the mechanisms of the anti-obesity effects of T3s are not yet understood. In…

A Very Rare Variant in SREBF2, a Possible Cause of Hypercholesterolemia and Increased Glycemic Levels

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A Very Rare Variant in SREBF2, a Possible Cause of Hypercholesterolemia and Increased Glycemic Levels   Abstract:   Patients with high cholesterol and glucose levels are at high risk for cardiovascular disease.The Sterol Regulatory Element Binding Protein (SREBP) system regulates genes involved in lipid,cholesterol and glucose pathways. Autosomal Dominant Hypercholesterolemias (ADHs) are a groupof diseases…

Setting your clock: associations between timing of objective physical activity and cardiovascular disease risk in the general population 

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Setting your clock: associations between timing of objective physical activity and cardiovascular disease risk in the general population    Abstract Aims   Little is known about the impact of daily physical activity timing (here referred to as ‘chronoactivity’) on cardiovascular disease (CVD) risk. We aimed to examined the associations between chronoactivity and multiple CVD outcomes…

The best diet for your blood pressure: 14 foods to eat, and 8 to avoid

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The DASH diet can help to keep hypertension under control   In many cases, what causes high blood pressure is mysterious. It’s attributed to a mixture of family history, age, stress levels, lifestyle factors, and health conditions. What’s not so uncertain? The treatments for this common condition. If you’re diagnosed with hypertension, there are established…

Timing of chocolate intake affects hunger, substrate oxidation, and microbiota: A randomized controlled trial

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Timing of chocolate intake affects hunger, substrate oxidation, and microbiota: A randomized controlled trial Abstract   Eating chocolate in the morning or in the evening/at night, may differentially affect energy balance and impact body weight due to changes in energy intake, substrate oxidation, microbiota (composition/function), and circadian-related variables. The research   In a randomized controlled…

Prospective Associations of Daily Step Counts and Intensity With Cancer and Cardiovascular Disease Incidence and Mortality and All-Cause Mortality

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Prospective Associations of Daily Step Counts and Intensity With Cancer and Cardiovascular Disease Incidence and Mortality and All-Cause Mortality   Key Points   Questions  What are the associations of daily step counts with cancer and cardiovascular disease incidence and mortality and all-cause mortality; and does the intensity of steps have additional benefits? Findings  This population-based prospective cohort…