Timing of daily calorie loading affects appetite and hunger responses without changes in energy metabolism in healthy subjects with obesity

Timing of daily calorie loading affects appetite and hunger responses without changes in energy metabolism in healthy subjects with obesity   Summary   Morning loaded calorie intake in humans has been advocated as a dietary strategy to improve weight loss. This is also supported by animal studies suggesting time of eating can prevent weight gain.…

Impact of Peanuts and Tree Nuts on Body Weight and Healthy Weight Loss in Adults

Impact of Peanuts and Tree Nuts on Body Weight and Healthy Weight Loss in Adults   Abstract   Nuts (ground and tree) are rich sources of multiple nutrients and their consumption is associated with health benefits, including reduced cardiovascular disease risk. This has prompted recommendations to increase their consumption. However, they are also high in…

Untangling the APOE4 Gene, the Most Significant Genetic Risk Factor for Alzheimer’s Disease

The genetic background around APOE region can modify the Alzheimer’s disease-associated APOE4 risk effects   Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia, affecting more than 5.8 million individuals in the U.S. Scientists have discovered some genetic variants that increase the risk for developing Alzheimer’s; the most well-known…

Pilot study of responsive nucleus accumbens deep brain stimulation for loss-of-control eating

Pilot study of responsive nucleus accumbens deep brain stimulation for loss-of-control eating   Abstract   Cravings that precede loss of control (LOC) over food consumption present an opportunity for intervention in patients with the binge eating disorder (BED). In this pilot study, we used responsive deep brain stimulation (DBS) to record nucleus accumbens (NAc) electrophysiology…

The risk of incident extrahepatic cancers is higher in non-alcoholic fatty liver disease than obesity

The risk of incident extrahepatic cancers is higher in non-alcoholic fatty liver disease than obesity – A longitudinal cohort study   Background & aims: Cancer is a major cause of death in patients with non-alcoholic fatty liver disease (NAFLD). Obesity is a risk factor for cancers; however, the role of NAFLD in this association is unknown.…

Molecular probe links high-fat diet to nitric oxide levels, cancer development

Molecular probe links high-fat diet to nitric oxide levels, cancer development   The study   Jeff Chan (left), an associate professor of chemistry at the University of Illinois Urbana-Champaign and the study’s principal investigator, and Anuj Yadav (right), a senior research associate and the study’s lead coauthor. It has long been hypothesized that dietary habits…

Beer, wine, and spirits differentially influence body composition in older white adults

Beer, wine, and spirits differentially influence body composition in older white adults–a United Kingdom Biobank study   Abstract BACKGROUND Aging is characterized by body composition alterations, including increased visceral adiposity accumulation and bone loss. Alcohol consumption may partially drive these alterations, but findings are mixed. This study primarily aimed to investigate whether different alcohol types…

Large-scale GWAS of food liking reveals genetic determinants and genetic correlations with distinct neurophysiological traits

Large-scale GWAS of food liking reveals genetic determinants and genetic correlations with distinct neurophysiological traits Abstract   We present the results of a GWAS of food liking conducted on 161,625 participants from the UK-Biobank. Liking was assessed over 139 specific foods using a 9-point scale. Genetic correlations coupled with structural equation modelling identified a multi-level…

High fat diets and synthetic substances in unregulated athletic performance enhancers fuels the progression of pancreatic cancer

Researchers at the University of Michigan Rogel Cancer Center have found a cell nuclear receptor activated by high fat diets and synthetic substances in unregulated athletic performance enhancers fuels the progression of precancerous pancreas lesions into pancreatic cancer.   Pancreatic ductal adenocarcinoma is a highly lethal form of cancer with rising occurrence, and strategies to prevent and…