Adipose tissue and blood leukocytes ACE2 DNA methylation in obesity and after weight loss

Background   Obesity was consistently associated with a poor prognosis in patients with COVID-19. Epigenetic mechanisms were proposed as the link between obesity and comorbidities risk.   Aim   To evaluate the methylation levels of angiotensin-converting enzyme 2 (ACE2) gene, the main entry receptor of SARS-CoV-2, in different depots of adipose tissue (AT) and leukocytes…

Adopting a High-Polyphenolic Diet Is Associated with an Improved Glucose Profile: Prospective Analysis within the PREDIMED-Plus Trial

Adopting a High-Polyphenolic Diet Is Associated with an Improved Glucose Profile: Prospective Analysis within the PREDIMED-Plus Trial   Previous studies suggested that dietary polyphenols could reduce the incidence and complications of type-2 diabetes (T2D); although the evidence is still limited and inconsistent. This work analyzes whether changing to a diet with a higher polyphenolic content…

Microsomal prostaglandin E synthase-1 is involved in the metabolic and cardiovascular alterations associated with obesity

Background and Purpose Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible isomerase responsible for prostaglandin E2 production in inflammatory conditions. We evaluated the role of mPGES-1 in the development and the metabolic and cardiovascular alterations of obesity. Experimental Approach mPGES-1+/+ and mPGES-1−/− mice were fed with normal or high fat diet (HFD, 60% fat). The glycaemic and lipid…

Higher olive oil intake associated with lower risk of CVD mortality

Replacing margarine, butter, mayonnaise and dairy fat with olive oil was associated with lower mortality risk Consuming more than 7 grams (>1/2 tablespoon) of olive oil per day is associated with lower risk of cardiovascular disease mortality, cancer mortality, neurodegenerative disease mortality and respiratory disease mortality, according to a study publishing today in the Journal…

Association of four genetic variants with colorectal cancer

Oncotarget published “Association of four genetic variants with colorectal cancer in Kazakhstan population” which reported that genotyping of SNPs was performed by QuantStudio 12K Flex PCR. For four significant SNPs inheritance model analysis was performed. Decreasing risk of CRC was noted for rs10506868 in the log-additive model.   The authors detected SNPs that are associated with…

Dietary palmitic acid promotes a prometastatic memory via Schwann cells

Dietary palmitic acid promotes a prometastatic memory via Schwann cells Gloria Pascual # 1, Diana Domínguez # 2, Marc Elosúa-Bayes 3, Felipe Beckedorff 4, Carmelo Laudanna 2, Claudia Bigas 2, Delphine Douillet 5, Carolina Greco 6, Aikaterini Symeonidi 2, Inmaculada Hernández 2 3, Sara Ruiz Gil 3, Neus Prats 2, Coro Bescós 7, Ramin Shiekhattar 4, Moran Amit 8, Holger Heyn 3, Ali Shilatifard 9, Salvador Aznar Benitah 10 11 Affiliations expand PMID: 34759321 DOI: 10.1038/s41586-021-04075-0 Abstract Fatty acid uptake and altered metabolism constitute hallmarks of metastasis1,2, yet evidence of the underlying biology, as well as whether…

What Is Nutrigenomics? The Science Of How Food Affects Genes, Explained

The ever-evolving field of nutrition research is pretty exciting—and at the intersection of food, nutrition, and our human genome is the wide spectrum of nutritional genomics research. What is that, you ask? Nutritional genomics research (aka nutrigenomics) explores how the food we eat and other environmental factors directly affect our genes’ functioning—specifically in regards to…