ONLINE ADVANCED COURSE ON NUTRIGENETICS AND NUTRIGENOMICS FOR PROFESSIONALS OF NUTRITION

1.1-What is Metabolomics?

1.2-Nutrigenomics, Metabolomics and diet. Genotype-phenotype relationship and nutritional treatments.

1.3-Role of Metabolomics in the identification of responders and non-responders.

1.4-Metabolic profiling as a diagnostic tool.

1.5-Examples of metabolic profiles for medical diagnosis.

1.6-Examples of the relationship between nutritional treatment and changes in metabolic profiles

2.1-Introduction to neurodegenerative diseases.
2.2-Molecular basis of neurodegenerative diseases.
2.3-Nutrigenomics and Alzheimer’s Disease (AD).

2.4-Nutrigenomics and Parkinson’s Disease (PD).

2.5-Nutrigenomics and Multiple Sclerosis (MS).

3.1-Molecular basis of aging.

3.2-Caloric restriction and modification of gen expression.
3.3-Mitochondrial genomics and aging.

4.1-Physiology of Satiety Mechanisms.
4.2-Monogenic variations related to satiety and intake control.
4.3-Variations in taste and food intake.
4.4-Polymorphisms related to satiety gut hormones.

4.5-Genome wide association studies and identification of possible pathways
involved.

4.6-Recommendations for Nutritional Treatments.

4.7-Conclusions.

5.1-Introduction to the importance of the Genetics of Osteoporosis.
5.2-Vitamin D receptor (VDR) gene polymorphisms.
5.3-Collagen type I alpha 1 (COL1A1) polymorphisms.
5.4-Estrogen receptor gene polymorphisms.

5.5-Lipid metabolism and osteoporosis.

5.6-B vitamins, oxidative stress and osteoporosis.

6.1-Introduction to the mechanisms involved in insulin resistance.
6.2-Polymorphisms related to metabolic syndrome..
6.3-Approach of nutritional treatments based on genetic polymorphisms.
6.4-Nutriepigenetics and insulin resistance.
6.5-Dietary treatments and epigenetics.

7.1.1- Introduction.

• What is metagenomics?.
• Metagenome sequencing methods.
• Terms: microbiota and microbiome.

7.1.2-The Human Microbiota.

• Microbial composition
• Gut Microbiota.
• Interindividual variability : microbial footprint.
• Main bacteria phyla. Enterotype classification.
• Development and stability of the microbiota.
• Main factors modulating the microbiota.
• Implication in human physiology.
• Main study models

7.2- Microbiota and metabolic syndrome – Obesity and insulin resistance –

• Gut microbiota as a key factor in the start and development of metabolic syndrome
• Short-chain fatty acids and metabolic syndrome
• Understanding the concept of microbiota-host symbiosis
• Gut-liver axis and non-alcoholic fatty liver disease (NAFLD)
• Gut microflora modulation as a therapeutic target
• Effect of probiotics on glycemic control
• Effect of artificial sweeteners, colonic microbiota and metabolic syndrome7.3- Microbiota and metabolic syndrome – Obesity and insulin resistance –

7.3- Microbiota and cardiovascular disease (CVD).

• Introduction: Is there a link between microbiota and CVD?.
• Oral microbiota and CVD.
• Gut Microbiota and CVD.
• Prebiotics and/or probiotics as strategies to treat CVD.

8.1-Introduction.
8.2-“Microbiota-gut-brain” axis: role of the microbiota in the development and physiology of the nervous system.

8.3-Microbiota and Neurodevelopmental Disorders.
8.4-Microbiota and Mental Disorders.

8.5-Microbiota and Neurodegenerative Disorders.

8.6-Gut microbiota modulation as a therapeutic strategy in Nervous System Diseases: use of prebiotics and/or probiotics.