Complete human day 14 post-implantation embryo models from naïve ES cells
The ability to study human post-implantation development remains limited due to ethical and technical challenges associated with intrauterine development after implantation1. Abstract Embryo-like models with spatially organized morphogenesis of all defining embryonic and extra-embryonic tissues of the post-implantation human conceptus (i.e., embryonic disk, bilaminar disk, yolk- and chorionic sacs, surrounding trophoblasts) remain lacking2.…