Large-scale GWAS of food liking reveals genetic determinants and genetic correlations with distinct neurophysiological traits

Large-scale GWAS of food liking reveals genetic determinants and genetic correlations with distinct neurophysiological traits Abstract   We present the results of a GWAS of food liking conducted on 161,625 participants from the UK-Biobank. Liking was assessed over 139 specific foods using a 9-point scale. Genetic correlations coupled with structural equation modelling identified a multi-level…

High fat diets and synthetic substances in unregulated athletic performance enhancers fuels the progression of pancreatic cancer

Researchers at the University of Michigan Rogel Cancer Center have found a cell nuclear receptor activated by high fat diets and synthetic substances in unregulated athletic performance enhancers fuels the progression of precancerous pancreas lesions into pancreatic cancer.   Pancreatic ductal adenocarcinoma is a highly lethal form of cancer with rising occurrence, and strategies to prevent and…

Beer, wine, and spirits differentially influence body composition in older white adults–a United Kingdom Biobank study

BACKGROUND   Aging is characterized by body composition alterations, including increased visceral adiposity accumulation and bone loss. Alcohol consumption may partially drive these alterations, but findings are mixed. This study primarily aimed to investigate whether different alcohol types (beer/cider, red wine, white wine/Champagne, spirits) differentially associated with body composition.   METHODS   The longitudinal UK…

Resistance and Endurance Exercise Training Induce Differential Changes in Gut Microbiota Composition in Murine Models

The effect of resistance training on gut microbiota composition has not been explored, despite the evidence about endurance exercise. The aim of this study was to compare the effect of resistance and endurance training on gut microbiota composition in mice.   Methods: Cecal samples were collected from 26 C57BL/6N mice, divided into three groups: sedentary (CTL),…

Adipose tissue and blood leukocytes ACE2 DNA methylation in obesity and after weight loss

Background   Obesity was consistently associated with a poor prognosis in patients with COVID-19. Epigenetic mechanisms were proposed as the link between obesity and comorbidities risk.   Aim   To evaluate the methylation levels of angiotensin-converting enzyme 2 (ACE2) gene, the main entry receptor of SARS-CoV-2, in different depots of adipose tissue (AT) and leukocytes…

Adopting a High-Polyphenolic Diet Is Associated with an Improved Glucose Profile: Prospective Analysis within the PREDIMED-Plus Trial

Adopting a High-Polyphenolic Diet Is Associated with an Improved Glucose Profile: Prospective Analysis within the PREDIMED-Plus Trial   Previous studies suggested that dietary polyphenols could reduce the incidence and complications of type-2 diabetes (T2D); although the evidence is still limited and inconsistent. This work analyzes whether changing to a diet with a higher polyphenolic content…

Microsomal prostaglandin E synthase-1 is involved in the metabolic and cardiovascular alterations associated with obesity

Background and Purpose Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible isomerase responsible for prostaglandin E2 production in inflammatory conditions. We evaluated the role of mPGES-1 in the development and the metabolic and cardiovascular alterations of obesity. Experimental Approach mPGES-1+/+ and mPGES-1−/− mice were fed with normal or high fat diet (HFD, 60% fat). The glycaemic and lipid…

Higher olive oil intake associated with lower risk of CVD mortality

Replacing margarine, butter, mayonnaise and dairy fat with olive oil was associated with lower mortality risk Consuming more than 7 grams (>1/2 tablespoon) of olive oil per day is associated with lower risk of cardiovascular disease mortality, cancer mortality, neurodegenerative disease mortality and respiratory disease mortality, according to a study publishing today in the Journal…