Dietary interventions and precision nutrition in cancer therapy

Highlights   Although the link between dietary intake and cancer has been studied for decades, the data on the anticancer effects of dietary interventions remain inconsistent. Recent studies have demonstrated the powerful potential of particular diets in preventing tumorigenesis, delaying tumor growth, and improving the effectiveness of existing cancer treatments. Understanding the interactions between cancer…

High adherence to Western dietary pattern and prostate cancer risk: findings from the EPIC-Spain cohort

Abstract Objective To explore the association between three previously identified dietary patterns (Western, Prudent and Mediterranean) and prostate cancer (PCa) risk by tumour aggressiveness.   Subjects and Methods The Spanish cohort of the European Prospective Investigation into Cancer and Nutrition study provided dietary and epidemiological information from 15 296 men recruited during the period 1992–1996. The…

Spirulina in Clinical Practice: Evidence-Based Human Applications

Spirulina in Clinical Practice: Evidence-Based Human Applications   Abstract Spirulina or Arthrospira is a blue-green alga that became famous after it was successfully used by NASA as a dietary supplement for astronauts on space missions. It has the ability to modulate immune functions and exhibits anti-inflammatory properties by inhibiting the release of histamine by mast cells. Multiple studies…

Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease

Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease   Question  What are the genetic associations between modifiable risk factors and Alzheimer disease (AD)? Findings  In this genetic association study using a mendelian randomization framework with the largest genomic data sets to date, including 39 106 participants with clinically diagnosed AD and 401 577 control participants without AD, genetically…

Improvement of cognitive function in wild-type and Alzheimer´s disease mouse models by the immunomodulatory properties of menthol inhalation or by depletion of T regulatory cells

A complex network of interactions exists between the olfactory, immune and central nervous systems. In this work we intend to investigate this connection through the use of an immunostimulatory odorant like menthol, analyzing its impact on the immune system and the cognitive capacity in healthy and Alzheimer’s Disease Mouse Models.   We first found that…