An important detail went largely unnoticed amid the celebrations two decades ago of the mapping of the human genome: The job wasn’t really done. The historic sequencing of the roughly 3 billion letters that represent the blueprint of humans was only about 92 percent complete. Scientists had done all they could do with the…
Study in animals suggests omega-3 may reduce effects Four weeks on a diet of highly processed food led to a strong inflammatory response in the brains of aging rats that was accompanied by behavioral signs of memory loss, a new study has found. Researchers also found that supplementing the processed diet with the omega-3 fatty…
Dietary palmitic acid promotes a prometastatic memory via Schwann cells Gloria Pascual # 1, Diana Domínguez # 2, Marc Elosúa-Bayes 3, Felipe Beckedorff 4, Carmelo Laudanna 2, Claudia Bigas 2, Delphine Douillet 5, Carolina Greco 6, Aikaterini Symeonidi 2, Inmaculada Hernández 2 3, Sara Ruiz Gil 3, Neus Prats 2, Coro Bescós 7, Ramin Shiekhattar 4, Moran Amit 8, Holger Heyn 3, Ali Shilatifard 9, Salvador Aznar Benitah 10 11 Affiliations expand PMID: 34759321 DOI: 10.1038/s41586-021-04075-0 Abstract Fatty acid uptake and altered metabolism constitute hallmarks of metastasis1,2, yet evidence of the underlying biology, as well as whether…
The ever-evolving field of nutrition research is pretty exciting—and at the intersection of food, nutrition, and our human genome is the wide spectrum of nutritional genomics research. What is that, you ask? Nutritional genomics research (aka nutrigenomics) explores how the food we eat and other environmental factors directly affect our genes’ functioning—specifically in regards to…
Type 1 diabetes and asthma: a systematic review and meta-analysis of observational studies Rong Zeng, Zihan Wang, Jintao Zhang, Ziting Liang, Changjuan Xu, Jing Wang & Liang Dong Endocrine volume 75, pages709–717 (2022)Cite this article 93 Accesses 3 Altmetric Metricsdetails Abstract Purpose Type 1 diabetes (T1D) and asthma are both the top concurrent non-communicable diseases in the world, and the existence…
Abstract Aims/hypothesis Psychiatric disorders, such as schizophrenia (SCZ), major depressive disorder (MDD) and bipolar disorder (BPD), are highly comorbid with type 2 diabetes. However, the mechanisms underlying such comorbidity are understudied. This study explored the familial aggregation of common psychiatric disorders and type 2 diabetes by testing family history association, and investigated the shared genetic…
In a study of just over 4000 middle-aged women in China, researchers found: A U-shaped relationship between low, normal, or high birth weight and risk of adult obesity, with the lowest risk at a birth weight of 3000 g (the midpoint of the normal birth weight range of 2500 g to < 3500 g).…
Short sleep duration has been recognized as a risk factor for obesity. Whether extending sleep duration may mitigate this risk remains unknown. Objective To determine the effects of a sleep extension intervention on objectively assessed energy intake, energy expenditure, and body weight in real-life settings among adults with overweight who habitually curtailed their sleep duration.…
3. Drugs There are several agents for the pharmacologic therapy of obesity leading to decreased appetite, gastric emptying, nutrient absorption, or increased satiety. Some of these have gained marketing authorization during the last six years, and some others are still under development process [94,95]. Currently, the European Medicines Agency (EMA) authorized three drugs (orlistat, naltrexone/bupropion,…
Microbiome-Based Dietary Recommendations Various correlations between the gut microbiota and individuals’ nutrition, as well as the occurrence of diseases like obesity, have been shown [59]. These correlations indicate that personalized nutrition based on the microbiome is a further starting point for weight loss [59]. Increasing evidence suggests that changes in individuals’ microbiome during dietary intervention…
2.1.3. Intermittent Fasting There are several approaches of intermittent fasting. The 16:8 concept is a form oftime-restricted eating where individuals eat within a time window of 8 h and fast for the remaining 16 h daily. The 5:2 concept consists of a normal eating routine on 5 days per week, without any specific recommendations or…
Abstract: Obesity caused by a positive energy balance is a serious health burden. Studies have shown that obesity is the major risk factor for many diseases like type 2 diabetes mellitus, coronary heart diseases, or various types of cancer. Therefore, the prevention and treatment of increased body weight are key. Different evidence-based treatment approaches considering weight history,…