Disease-specific loss of microbial cross-feeding interactions in the human gut

Many gut microorganisms critical to human health rely on nutrients produced by each other for survival; however, these cross-feeding interactions are still challenging to quantify and remain poorly characterized.   Abstract Here, we introduce a Metabolite Exchange Score (MES) to quantify those interactions. Using metabolic models of prokaryotic metagenome-assembled genomes from over 1600 individuals, MES…

Gut Microbiomes Offer Insights into Chronic Fatigue Syndrome

Levels of health-promoting gut bacteria are linked with severity of fatigue symptoms, a study finds.   Millions of people are affected by the debilitating exhaustion and brain fog that characterizes the long-term condition chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis. Although CFS has been connected to viral infections including COVID-19, the underlying cause of the…