The yo-yo effect: Adipose tissue retains an epigenetic memory of obesity after weight loss
Abstract Reducing body weight to improve metabolic health and related comorbidities is a primary goal in treating obesity1,2. However, maintaining weight loss is a considerable challenge, especially as the body seems to retain an obesogenic memory that defends against body weight changes 3,4. Overcoming this barrier for long-term treatment success is difficult because the molecular…