Upper small intestine microbiome in obesity and related metabolic disorders: A new field of investigation

Highlights Upper small intestine (USI) microbiome is crucial in nutrient absorption and digestion. High-fat diet greatly impacts USI microbiome diversity and composition in rodents. Bariatric surgery and inulin aid in the recovery of USI microbiome in HFD-fed mice Metagenomic richness of USI microbiome inversely correlates with insulin resistance. USI microbiome research in obesity is still…