A vaccine lowers LDL-cholesterol levels in non-human primates
A virus-like particle-based bivalent PCSK9 vaccine lowers LDL-cholesterol levels in non-human primates Abstract Elevated low-density lipoprotein cholesterol (LDL-C) is an important risk factor in the development of atherosclerotic cardiovascular disease (ASCVD). Inhibitors of proprotein convertase subtilisin/kexin type 9 (PCSK9), a negative regulator of LDL-C metabolism, have emerged as promising approaches for reducing elevated…