Surprise finding reveals mitochondrial ‘energy factories’ come in two different types

  Mitochondria divide to share the load when nutrients are scarce — plus, how smashing atomic nuclei together helps identify their shapes. Researchers have uncovered that mitochondria divide into two distinct forms when cells are starved, a finding that could help explain how some cancers thrive in hostile conditions. Mitochondria are cellular powerhouses, creating energy…

Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk

  Abstract   High protein intake is common in western societies and is often promoted as part of a healthy lifestyle; however, amino-acid-mediated mammalian target of rapamycin (mTOR) signalling in macrophages has been implicated in the pathogenesis of ischaemic cardiovascular disease. In a series of clinical studies on male and female participants (NCT03946774 and NCT03994367) that involved…

These silent diseases are those that damage the liver without an effective treatment to stop them.

  Patients suffering from fatty liver and alcoholic liver disease are becoming more frequent. Experts warn that alcohol consumption in Spain is considered the most frequent cause of chronic liver disease.     The  83rd Congress of the Spanish Society of Digestive Pathology  (SEPD) has devoted a significant amount of space and interest to liver health and…

Diet-gut microbiota-epigenetics in metabolic diseases: From mechanisms to therapeutics

  Abstract The prevalence of metabolic diseases, including obesity, dyslipidemia, type 2 diabetes mellitus (T2DM), and non-alcoholic fatty liver disease (NAFLD), is a severe burden in human society owing to the ensuing high morbidity and mortality.   Various factors linked to metabolic disorders, particularly environmental factors (such as diet and gut microbiota) and epigenetic modifications,…