The yo-yo effect: Adipose tissue retains an epigenetic memory of obesity after weight loss

Abstract Reducing body weight to improve metabolic health and related comorbidities is a primary goal in treating obesity1,2. However, maintaining weight loss is a considerable challenge, especially as the body seems to retain an obesogenic memory that defends against body weight changes 3,4. Overcoming this barrier for long-term treatment success is difficult because the molecular…

The Role of Gut Microbiome in Sleep Quality and Health: Dietary Strategies for Microbiota Support

Abstract   Dietary components, including dietary fiber, unsaturated fatty acids, and polyphenols, along with meal timing and spacing, significantly affect the microbiota’s capacity to produce various metabolites essential for quality sleep and overall health. This review explores the role of gut microbiota in regulating sleep through various metabolites such as short-chain fatty acids, tryptophan, serotonin,…

Effect of Methylfolate, Pyridoxal-5′-Phosphate, and Methylcobalamin vitamin B supplementation

Effect of Methylfolate, Pyridoxal-5′-Phosphate, and Methylcobalamin (SolowaysTM) Supplementation on Homocysteine and Low-Density Lipoprotein Cholesterol Levels in Patients with Methylenetetrahydrofolate Reductase, Methionine Synthase, and Methionine Synthase Reductase Polymorphisms: A Randomized Controlled Trial   Abstract   Exploring the link between genetic polymorphisms in folate metabolism genes (MTHFR, MTR, and MTRR) and cardiovascular disease (CVD), this study evaluates…

Surprise finding reveals mitochondrial ‘energy factories’ come in two different types

  Mitochondria divide to share the load when nutrients are scarce — plus, how smashing atomic nuclei together helps identify their shapes. Researchers have uncovered that mitochondria divide into two distinct forms when cells are starved, a finding that could help explain how some cancers thrive in hostile conditions. Mitochondria are cellular powerhouses, creating energy…