The genetic background around APOE region can modify the Alzheimer’s disease-associated APOE4 risk effects Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia, affecting more than 5.8 million individuals in the U.S. Scientists have discovered some genetic variants that increase the risk for developing Alzheimer’s; the most well-known…
Pilot study of responsive nucleus accumbens deep brain stimulation for loss-of-control eating Abstract Cravings that precede loss of control (LOC) over food consumption present an opportunity for intervention in patients with the binge eating disorder (BED). In this pilot study, we used responsive deep brain stimulation (DBS) to record nucleus accumbens (NAc) electrophysiology…
The risk of incident extrahepatic cancers is higher in non-alcoholic fatty liver disease than obesity – A longitudinal cohort study Background & aims: Cancer is a major cause of death in patients with non-alcoholic fatty liver disease (NAFLD). Obesity is a risk factor for cancers; however, the role of NAFLD in this association is unknown.…
Molecular probe links high-fat diet to nitric oxide levels, cancer development The study Jeff Chan (left), an associate professor of chemistry at the University of Illinois Urbana-Champaign and the study’s principal investigator, and Anuj Yadav (right), a senior research associate and the study’s lead coauthor. It has long been hypothesized that dietary habits…
Beer, wine, and spirits differentially influence body composition in older white adults–a United Kingdom Biobank study Abstract BACKGROUND Aging is characterized by body composition alterations, including increased visceral adiposity accumulation and bone loss. Alcohol consumption may partially drive these alterations, but findings are mixed. This study primarily aimed to investigate whether different alcohol types…
Large-scale GWAS of food liking reveals genetic determinants and genetic correlations with distinct neurophysiological traits Abstract We present the results of a GWAS of food liking conducted on 161,625 participants from the UK-Biobank. Liking was assessed over 139 specific foods using a 9-point scale. Genetic correlations coupled with structural equation modelling identified a multi-level…
Researchers at the University of Michigan Rogel Cancer Center have found a cell nuclear receptor activated by high fat diets and synthetic substances in unregulated athletic performance enhancers fuels the progression of precancerous pancreas lesions into pancreatic cancer. Pancreatic ductal adenocarcinoma is a highly lethal form of cancer with rising occurrence, and strategies to prevent and…
People in Wales affected by mental health issues will be able to benefit from a new genetics service. Individuals with certain genetic alterations have a much greater risk of developing serious conditions such as schizophrenia, according to research. The new NHS Wales service, the first of its kind in the UK, offers patients and…
BACKGROUND Aging is characterized by body composition alterations, including increased visceral adiposity accumulation and bone loss. Alcohol consumption may partially drive these alterations, but findings are mixed. This study primarily aimed to investigate whether different alcohol types (beer/cider, red wine, white wine/Champagne, spirits) differentially associated with body composition. METHODS The longitudinal UK…
Polygenic scores, diet quality, and type 2 diabetes risk: An observational study among 35,759 adults from 3 US cohorts Background Both genetic and lifestyle factors contribute to the risk of type 2 diabetes, but the extent to which there is a synergistic effect of the 2 factors is unclear. The aim of this study…
The effect of resistance training on gut microbiota composition has not been explored, despite the evidence about endurance exercise. The aim of this study was to compare the effect of resistance and endurance training on gut microbiota composition in mice. Methods: Cecal samples were collected from 26 C57BL/6N mice, divided into three groups: sedentary (CTL),…
Background Obesity was consistently associated with a poor prognosis in patients with COVID-19. Epigenetic mechanisms were proposed as the link between obesity and comorbidities risk. Aim To evaluate the methylation levels of angiotensin-converting enzyme 2 (ACE2) gene, the main entry receptor of SARS-CoV-2, in different depots of adipose tissue (AT) and leukocytes…