Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk

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  Abstract   High protein intake is common in western societies and is often promoted as part of a healthy lifestyle; however, amino-acid-mediated mammalian target of rapamycin (mTOR) signalling in macrophages has been implicated in the pathogenesis of ischaemic cardiovascular disease. In a series of clinical studies on male and female participants (NCT03946774 and NCT03994367) that involved…

These silent diseases are those that damage the liver without an effective treatment to stop them.

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  Patients suffering from fatty liver and alcoholic liver disease are becoming more frequent. Experts warn that alcohol consumption in Spain is considered the most frequent cause of chronic liver disease.     The  83rd Congress of the Spanish Society of Digestive Pathology  (SEPD) has devoted a significant amount of space and interest to liver health and…

Diet-gut microbiota-epigenetics in metabolic diseases: From mechanisms to therapeutics

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  Abstract The prevalence of metabolic diseases, including obesity, dyslipidemia, type 2 diabetes mellitus (T2DM), and non-alcoholic fatty liver disease (NAFLD), is a severe burden in human society owing to the ensuing high morbidity and mortality.   Various factors linked to metabolic disorders, particularly environmental factors (such as diet and gut microbiota) and epigenetic modifications,…

This food increases the possibility of developing diabetes even though it has no sugar, according to Harvard

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The study analyzed 200,000 volunteers and concluded that it produced a 26% increase.   While type 1 diabetes is usually caused by an autoimmune disease, type 2 diabetes is often linked to different lifestyle factors, such as a high-sugar diet, a sedentary lifestyle, smoking, being overweight, etc. Thus, most people who want to avoid type…

Longevity and fertility: what are the latest developments discussed at the global summit of experts in assisted reproduction?

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  Dr. Ester Polak de Fried, a pioneer and expert in fertilization in Latin America, told Infobae about the latest developments in treatments and the dilemmas faced by the increase in life expectancy and the postponement of motherhood. Recently returned from the 40th European Congress of Reproduction and Embryology in Amsterdam, she said: “There is…

Beyond the body mass index: a new obesity diagnosis to bring it closer to reality

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  Nearly two centuries ago , Adolphe Quetelet , a Belgian astronomer and mathematician interested in defining the characteristics of the “normal man,” began collecting  data on body measurements from Western European men . He concluded that weight was roughly related to the square of height , which led to the formulation of the  index that bears his name in 1833 . However, Quetelet ‘s proposal was…

These silent diseases are those that damage the liver without effective treatment to stop them

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  Patients suffering from fatty liver and alcoholic liver disease are becoming more common. Experts warn that alcohol consumption in Spain is considered the most common cause of chronic liver disease   The 83rd Congress of the Spanish Society of Digestive Pathology (SEPD), has dedicated an important space and interest to liver health and pathologies. In this…

They prove that the contribution of scientist Rosalind Franklin was essential to understanding the structure of DNA

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  Researchers in the history of science published in Nature magazine how the contribution of British chemistry was hidden and the way in which a legend was built that covered up the result of their work.     DNA is the popular molecule that makes up the cells of organisms on the planet. 70 years ago James Watson and…