The Role of Gut Microbiome in Sleep Quality and Health: Dietary Strategies for Microbiota Support

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Abstract   Dietary components, including dietary fiber, unsaturated fatty acids, and polyphenols, along with meal timing and spacing, significantly affect the microbiota’s capacity to produce various metabolites essential for quality sleep and overall health. This review explores the role of gut microbiota in regulating sleep through various metabolites such as short-chain fatty acids, tryptophan, serotonin,…

Effect of Methylfolate, Pyridoxal-5′-Phosphate, and Methylcobalamin vitamin B supplementation

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Effect of Methylfolate, Pyridoxal-5′-Phosphate, and Methylcobalamin (SolowaysTM) Supplementation on Homocysteine and Low-Density Lipoprotein Cholesterol Levels in Patients with Methylenetetrahydrofolate Reductase, Methionine Synthase, and Methionine Synthase Reductase Polymorphisms: A Randomized Controlled Trial   Abstract   Exploring the link between genetic polymorphisms in folate metabolism genes (MTHFR, MTR, and MTRR) and cardiovascular disease (CVD), this study evaluates…

Surprise finding reveals mitochondrial ‘energy factories’ come in two different types

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  Mitochondria divide to share the load when nutrients are scarce — plus, how smashing atomic nuclei together helps identify their shapes. Researchers have uncovered that mitochondria divide into two distinct forms when cells are starved, a finding that could help explain how some cancers thrive in hostile conditions. Mitochondria are cellular powerhouses, creating energy…

Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk

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  Abstract   High protein intake is common in western societies and is often promoted as part of a healthy lifestyle; however, amino-acid-mediated mammalian target of rapamycin (mTOR) signalling in macrophages has been implicated in the pathogenesis of ischaemic cardiovascular disease. In a series of clinical studies on male and female participants (NCT03946774 and NCT03994367) that involved…