Coffee Intake, Plasma Caffeine Levels, and Kidney Function: Two-Sample Mendelian Randomization Among East Asian and European Ancestries

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  Coffee Intake, Plasma Caffeine Levels, and Kidney Function: Two-Sample Mendelian Randomization Among East Asian and European Ancestries Introduction   Previous Mendelian randomization (MR) studies for the coffee-kidney association have reported inconsistent relationships in European populations and never examined mediators of this association. We aimed to evaluate this causal relationship using two-sample MR among both…

Cells regeneration and longevity can have an impact on osteporosis and diabetes

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For over 25 years, Dr. Robert Sackstein has extensively investigated the structures that direct cell migration in blood flow, such as those molecules that cause braking on E-selectin.   Collectively, these molecules are called the “homing receptors” because they act as the navigators in directing thehoming of cells into tissues. All cells that gain entry…

Yogurt: Nutrition facts

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Yogurt: The Nutrition Source   Yogurt is a staple food in several cultures, originating from countries in Western Asia and the Middle East. The word yogurt is believed to be derived from the Turkish word “yoğurmak,” which means to thicken, coagulate, or curdle. Historical accounts describe nomadic herdsmen carrying milk in pouches made of animal…

A vaccine lowers LDL-cholesterol levels in non-human primates

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A virus-like particle-based bivalent PCSK9 vaccine lowers LDL-cholesterol levels in non-human primates     Abstract Elevated low-density lipoprotein cholesterol (LDL-C) is an important risk factor in the development of atherosclerotic cardiovascular disease (ASCVD). Inhibitors of proprotein convertase subtilisin/kexin type 9 (PCSK9), a negative regulator of LDL-C metabolism, have emerged as promising approaches for reducing elevated…

The Role of Gut Microbiota in Some Liver Diseases: From an Immunological Perspective

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Abstract   Gut microbiota is a microecosystem composed of various microorganisms. It plays an important role in human metabolism, and its metabolites affect different tissues and organs. Intestinal flora maintains the intestinal mucosal barrier and interacts with the immune system. The liver is closely linked to the intestine by the gut-liver axis.  As the first…