Upper small intestine microbiome in obesity and related metabolic disorders: A new field of investigation

Highlights Upper small intestine (USI) microbiome is crucial in nutrient absorption and digestion. High-fat diet greatly impacts USI microbiome diversity and composition in rodents. Bariatric surgery and inulin aid in the recovery of USI microbiome in HFD-fed mice Metagenomic richness of USI microbiome inversely correlates with insulin resistance. USI microbiome research in obesity is still…

THE HUMAN MICROBIOME: 2023 PRINCESS OF ASTURIAS AWARD FOR TECHNICAL & SCIENTIFIC RESEARCH

JEFFREY GORDON, E. PETER GREENBERG AND BONNIE L. BASSLER 2023 PRINCESS OF ASTURIAS AWARD FOR TECHNICAL & SCIENTIFIC RESEARCH Jeffrey Gordon has spearheaded the study of the human microbiome, the set of microorganisms that inhabit our intestines (tens of trillions: several times more than the total number of our own cells), and their influence on…

Scientists discover evidence that being a vegetarian may be written in your genes

Researchers identified genes in vegetarians that may explain why they choose plant-based diets after screening 330,00 genomes.   Vegetarianism has been practiced for millennia in different societies and cultures, but today only a small minority of people forgo eating meat.   People turn to a meatless diet for ethical reasons, such as animal well-being or…

The largest ever study of the genetics of the brain by U. Cambridge has identified more than 4,000 genetic variants

The largest ever study of the genetics of the brain – encompassing some 36,000 brain scans – has identified more than 4,000 genetic variants linked to brain structure. The results of the study, led by researchers at the University of Cambridge, are published in Nature Genetics.   Our findings can be used to understand how changes…

Complete human day 14 post-implantation embryo models from naïve ES cells

The ability to study human post-implantation development remains limited due to ethical and technical challenges associated with intrauterine development after implantation1.   Abstract   Embryo-like models with spatially organized morphogenesis of all defining embryonic and extra-embryonic tissues of the post-implantation human conceptus (i.e., embryonic disk, bilaminar disk, yolk- and chorionic sacs, surrounding trophoblasts) remain lacking2.…

Dietary interventions and precision nutrition in cancer therapy

Highlights   Although the link between dietary intake and cancer has been studied for decades, the data on the anticancer effects of dietary interventions remain inconsistent. Recent studies have demonstrated the powerful potential of particular diets in preventing tumorigenesis, delaying tumor growth, and improving the effectiveness of existing cancer treatments. Understanding the interactions between cancer…