Familial aggregation and shared genetic loading for major psychiatric disorders and type 2 diabetes

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Abstract Aims/hypothesis Psychiatric disorders, such as schizophrenia (SCZ), major depressive disorder (MDD) and bipolar disorder (BPD), are highly comorbid with type 2 diabetes. However, the mechanisms underlying such comorbidity are understudied. This study explored the familial aggregation of common psychiatric disorders and type 2 diabetes by testing family history association, and investigated the shared genetic…

Effect of Sleep Extension on Objectively Assessed Energy Intake Among Adults With Overweight in Real-life Settings: A Randomized Clinical Trial

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Short sleep duration has been recognized as a risk factor for obesity. Whether extending sleep duration may mitigate this risk remains unknown. Objective To determine the effects of a sleep extension intervention on objectively assessed energy intake, energy expenditure, and body weight in real-life settings among adults with overweight who habitually curtailed their sleep duration.…

Nutrition Concepts for the Treatment of Obesity in Adults. Part 5-5.

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3. Drugs There are several agents for the pharmacologic therapy of obesity leading to decreased appetite, gastric emptying, nutrient absorption, or increased satiety. Some of these have gained marketing authorization during the last six years, and some others are still under development process [94,95]. Currently, the European Medicines Agency (EMA) authorized three drugs (orlistat, naltrexone/bupropion,…

Nutrition Concepts for the Treatment of Obesity in Adults. Part 4-5.

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Microbiome-Based Dietary Recommendations Various correlations between the gut microbiota and individuals’ nutrition, as well as the occurrence of diseases like obesity, have been shown [59]. These correlations indicate that personalized nutrition based on the microbiome is a further starting point for weight loss [59]. Increasing evidence suggests that changes in individuals’ microbiome during dietary intervention…

Nutrition Concepts for the Treatment of Obesity in Adults. Part 2-5.

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Abstract: Obesity caused by a positive energy balance is a serious health burden. Studies have shown that obesity is the major risk factor for many diseases like type 2 diabetes mellitus, coronary heart diseases, or various types of cancer. Therefore, the prevention and treatment of increased body weight are key. Different evidence-based treatment approaches considering weight history,…

Glucose control is a key factor in reducing cancer risk in obesity and type 2 diabetes

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Effective glucose control is important in reducing the risk of cancer in obesity and type 2 diabetes. Substantial, lasting weight loss appears to provide protection against cancer, but with effective glucose control, the number of cancer cases also drops dramatically, a University of Gothenburg study shows.   The study   It’s a known fact that…