High adherence to Western dietary pattern and prostate cancer risk: findings from the EPIC-Spain cohort

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Abstract Objective To explore the association between three previously identified dietary patterns (Western, Prudent and Mediterranean) and prostate cancer (PCa) risk by tumour aggressiveness.   Subjects and Methods The Spanish cohort of the European Prospective Investigation into Cancer and Nutrition study provided dietary and epidemiological information from 15 296 men recruited during the period 1992–1996. The…

Spirulina in Clinical Practice: Evidence-Based Human Applications

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Spirulina in Clinical Practice: Evidence-Based Human Applications   Abstract Spirulina or Arthrospira is a blue-green alga that became famous after it was successfully used by NASA as a dietary supplement for astronauts on space missions. It has the ability to modulate immune functions and exhibits anti-inflammatory properties by inhibiting the release of histamine by mast cells. Multiple studies…

Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease

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Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease   Question  What are the genetic associations between modifiable risk factors and Alzheimer disease (AD)? Findings  In this genetic association study using a mendelian randomization framework with the largest genomic data sets to date, including 39 106 participants with clinically diagnosed AD and 401 577 control participants without AD, genetically…

Improvement of cognitive function in wild-type and Alzheimer´s disease mouse models by the immunomodulatory properties of menthol inhalation or by depletion of T regulatory cells

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A complex network of interactions exists between the olfactory, immune and central nervous systems. In this work we intend to investigate this connection through the use of an immunostimulatory odorant like menthol, analyzing its impact on the immune system and the cognitive capacity in healthy and Alzheimer’s Disease Mouse Models.   We first found that…

Alirocumab and Coronary Atherosclerosis in Asymptomatic Patients with Familial Hypercholesterolemia: The ARCHITECT Study

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  Alirocumab and Coronary Atherosclerosis in Asymptomatic Patients with Familial Hypercholesterolemia: The ARCHITECT Study     Abstract Background: The effect of alirocumab, a PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor, on coronary plaque burden in patients with familial hypercholesterolemia has not been addressed. Our aim was to assess changes in coronary plaque burden and its characteristics…

WHO advises not to use non-sugar sweeteners for weight control in newly released guideline

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WHO advises not to use non-sugar sweeteners for weight control in newly released guideline   The World Health Organization (WHO) has released a new guideline on non-sugar sweeteners (NSS), which recommends against the use of NSS to control body weight or reduce the risk of noncommunicable diseases (NCDs). The recommendation is based on the findings…