The largest ever study of the genetics of the brain – encompassing some 36,000 brain scans – has identified more than 4,000 genetic variants linked to brain structure. The results of the study, led by researchers at the University of Cambridge, are published in Nature Genetics. Our findings can be used to understand how changes…
The ability to study human post-implantation development remains limited due to ethical and technical challenges associated with intrauterine development after implantation1. Abstract Embryo-like models with spatially organized morphogenesis of all defining embryonic and extra-embryonic tissues of the post-implantation human conceptus (i.e., embryonic disk, bilaminar disk, yolk- and chorionic sacs, surrounding trophoblasts) remain lacking2.…
Nearly three in four adults are considered overweight or obese. How can you lose weight and keep it off as you age? We are quite a large nation — not only in square footage, but in girth. Results from the 2017–2018 National Health and Nutrition Examination Survey found that about 73% of American…
Highlights Although the link between dietary intake and cancer has been studied for decades, the data on the anticancer effects of dietary interventions remain inconsistent. Recent studies have demonstrated the powerful potential of particular diets in preventing tumorigenesis, delaying tumor growth, and improving the effectiveness of existing cancer treatments. Understanding the interactions between cancer…
Abstract Objective To explore the association between three previously identified dietary patterns (Western, Prudent and Mediterranean) and prostate cancer (PCa) risk by tumour aggressiveness. Subjects and Methods The Spanish cohort of the European Prospective Investigation into Cancer and Nutrition study provided dietary and epidemiological information from 15 296 men recruited during the period 1992–1996. The…
Drug Trials Snapshots: NEXLETOL NEXLETOL (bempedoic acid) nex’ leh tol Esperion Approval date: February 21, 2020 DRUG TRIALS SNAPSHOT SUMMARY: What is the drug for? NEXLETOL is a drug for the treatment of high LDL cholesterol, which is sometimes referred to as “bad cholesterol”. NEXLETOL is to be used in the following two…
Abstract Purpose: We analyzed the association between salivary melatonin rhythm and prostate cancer (PCa). Materials and methods: A total of 40 PCa cases and 41 controls from the CAPLIFE study were analyzed to determine the salivary melatonin rhythm through 6 saliva samples. Amplitude (maximum melatonin peak) was categorized as low or high…
We Live in Florida. Do We Still Need to Worry About Our Vitamin D Levels? Around the world, about 1 billion people are vitamin D deficient, and they are found in both sunny and rainy climates. We may live in the Sunshine State, but some of us are still deficient in the “sunshine vitamin”:…
Spirulina in Clinical Practice: Evidence-Based Human Applications Abstract Spirulina or Arthrospira is a blue-green alga that became famous after it was successfully used by NASA as a dietary supplement for astronauts on space missions. It has the ability to modulate immune functions and exhibits anti-inflammatory properties by inhibiting the release of histamine by mast cells. Multiple studies…
Syncytial nerve net in a ctenophore adds insights on the evolution of nervous systems View of an ancient brain The evolutionary origin of nervous systems remains a fundamental question in biology. A hallmark of nervous systems is that they are composed of discrete cells (neurons) that communicate through synapses. Ctenophores, a sister group to…
Are collagen products worthwhile for skin, nails, and hair? A tremendous buzz surrounds collagen drinks and supplements, as celebrities and influencers tout miraculous benefits for skin, hair, and nails. Since the collagen in our bodies provides crucial support for these tissues, it seems plausible that consuming collagen might lead to lush locks and…
Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease Question What are the genetic associations between modifiable risk factors and Alzheimer disease (AD)? Findings In this genetic association study using a mendelian randomization framework with the largest genomic data sets to date, including 39 106 participants with clinically diagnosed AD and 401 577 control participants without AD, genetically…