Is early-onset cancer an emerging global epidemic? Current evidence and future implications Abstract Over the past several decades, the incidence of early-onset cancers, often defined as cancers diagnosed in adults <50 years of age, in the breast, colorectum, endometrium, oesophagus, extrahepatic bile duct, gallbladder, head and neck, kidney, liver, bone marrow, pancreas,…
Ultra-processed food consumption, cancer risk and cancer mortality: a large-scale prospective analysis within the UK Biobank Background Global dietary patterns are increasingly dominated by relatively cheap, highly palatable, and ready-to-eat ultra-processed foods (UPFs). However, prospective evidence is limited on cancer development and mortality in relation to UPF consumption. This study examines associations between UPF…
Results of phase 3 trials testing gantenerumab are latest blow to amyloid hypothesis The second (and third) time was not the charm for Roche’s experimental antibody drug for Alzheimer’s disease. The company last night announced gantenerumab had failed to show a statistically significant benefit in two large, late-stage clinical trials that tested its ability to…
Fish is among the foods exerting favourable effects on colorectal cancer (CRC), but the possible role of canned fish has been insufficiently investigated. The research We aimed to investigate the relationship between canned fish consumption and CRC risk. We analysed data from two case–control studies conducted between 1992 and 2010 in several Italian…
Tocotrienols Attenuate White Adipose Tissue Accumulation and Improve Serum Cholesterol Concentration in High-Fat Diet-Treated Mice Tocotrienols (T3s), which are vitamin E homologs, have not only antioxidant function but also inhibitory effects on body weight gain and hepatic lipid droplet accumulation. However, the mechanisms of the anti-obesity effects of T3s are not yet understood. In…
The Best and Worst Foods for Acid Reflux A hot burning in the chest, a bitter taste in the throat, a gassy bloating in the stomach – acid reflux is no picnic. What you eat, however, can have an impact. The best and worst foods for acid reflux could spell the difference between sweet…
A Very Rare Variant in SREBF2, a Possible Cause of Hypercholesterolemia and Increased Glycemic Levels Abstract: Patients with high cholesterol and glucose levels are at high risk for cardiovascular disease.The Sterol Regulatory Element Binding Protein (SREBP) system regulates genes involved in lipid,cholesterol and glucose pathways. Autosomal Dominant Hypercholesterolemias (ADHs) are a groupof diseases…
Setting your clock: associations between timing of objective physical activity and cardiovascular disease risk in the general population Abstract Aims Little is known about the impact of daily physical activity timing (here referred to as ‘chronoactivity’) on cardiovascular disease (CVD) risk. We aimed to examined the associations between chronoactivity and multiple CVD outcomes…
The DASH diet can help to keep hypertension under control In many cases, what causes high blood pressure is mysterious. It’s attributed to a mixture of family history, age, stress levels, lifestyle factors, and health conditions. What’s not so uncertain? The treatments for this common condition. If you’re diagnosed with hypertension, there are established…
The microbiome, or collection of friendly bacteria that resides in your gut, has been a buzzy topic in the health world for a while now. Research continues to uncover the many ways this collection of microorganisms impacts health. But what not everyone may know is that microbes don’t just reside in your digestive tract. Your…
Doctors are learning that one of the best ways to reduce inflammation lies not in the medicine cabinet, but in the refrigerator. By following an anti-inflammatory diet you can fight off inflammation for good. What does an anti-inflammatory diet do? Your immune system becomes activated when your body recognizes anything that is foreign—such as…
Timing of chocolate intake affects hunger, substrate oxidation, and microbiota: A randomized controlled trial Abstract Eating chocolate in the morning or in the evening/at night, may differentially affect energy balance and impact body weight due to changes in energy intake, substrate oxidation, microbiota (composition/function), and circadian-related variables. The research In a randomized controlled…