Timing of chocolate intake affects hunger, substrate oxidation, and microbiota: A randomized controlled trial

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Timing of chocolate intake affects hunger, substrate oxidation, and microbiota: A randomized controlled trial Abstract   Eating chocolate in the morning or in the evening/at night, may differentially affect energy balance and impact body weight due to changes in energy intake, substrate oxidation, microbiota (composition/function), and circadian-related variables. The research   In a randomized controlled…

Prospective Associations of Daily Step Counts and Intensity With Cancer and Cardiovascular Disease Incidence and Mortality and All-Cause Mortality

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Prospective Associations of Daily Step Counts and Intensity With Cancer and Cardiovascular Disease Incidence and Mortality and All-Cause Mortality   Key Points   Questions  What are the associations of daily step counts with cancer and cardiovascular disease incidence and mortality and all-cause mortality; and does the intensity of steps have additional benefits? Findings  This population-based prospective cohort…

Timing of daily calorie loading affects appetite and hunger responses without changes in energy metabolism in healthy subjects with obesity

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Timing of daily calorie loading affects appetite and hunger responses without changes in energy metabolism in healthy subjects with obesity   Summary   Morning loaded calorie intake in humans has been advocated as a dietary strategy to improve weight loss. This is also supported by animal studies suggesting time of eating can prevent weight gain.…

Impact of Peanuts and Tree Nuts on Body Weight and Healthy Weight Loss in Adults

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Impact of Peanuts and Tree Nuts on Body Weight and Healthy Weight Loss in Adults   Abstract   Nuts (ground and tree) are rich sources of multiple nutrients and their consumption is associated with health benefits, including reduced cardiovascular disease risk. This has prompted recommendations to increase their consumption. However, they are also high in…

Untangling the APOE4 Gene, the Most Significant Genetic Risk Factor for Alzheimer’s Disease

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The genetic background around APOE region can modify the Alzheimer’s disease-associated APOE4 risk effects   Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia, affecting more than 5.8 million individuals in the U.S. Scientists have discovered some genetic variants that increase the risk for developing Alzheimer’s; the most well-known…

Pilot study of responsive nucleus accumbens deep brain stimulation for loss-of-control eating

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Pilot study of responsive nucleus accumbens deep brain stimulation for loss-of-control eating   Abstract   Cravings that precede loss of control (LOC) over food consumption present an opportunity for intervention in patients with the binge eating disorder (BED). In this pilot study, we used responsive deep brain stimulation (DBS) to record nucleus accumbens (NAc) electrophysiology…

The risk of incident extrahepatic cancers is higher in non-alcoholic fatty liver disease than obesity

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The risk of incident extrahepatic cancers is higher in non-alcoholic fatty liver disease than obesity – A longitudinal cohort study   Background & aims: Cancer is a major cause of death in patients with non-alcoholic fatty liver disease (NAFLD). Obesity is a risk factor for cancers; however, the role of NAFLD in this association is unknown.…